Autoimmune Effect of Antibodies against the SARS-CoV-2 Nucleoprotein.

ABSTRACT: COVID-19 caused by SARS-CoV-2 is continuing to spread around the world and drastically affect our daily life. New strains appear, and the severity of the course of the disease itself seems to be decreasing, but even people who have been ill on an outpatient basis suffer post-COVID consequences. Partly, it is associated with the autoimmune reactions, so debates about the development of new vaccines and the need for vaccination/revaccination continue. In this study we performed an analysis of the antibody response of patients with COVID-19 to linear and conformational epitopes of viral proteins using ELISA, chip array and western blot with analysis of correlations between antibody titer, disease severity, and complications. We have shown that the presence of IgG antibodies to the nucleoprote

SUBMITTER: Matyushkina D 

PROVIDER: S-EPMC9228376 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature