Evaluation of Toxic Properties of New Glycopeptide Flavancin on Rats.

ABSTRACT: Glycopeptide antibiotics have side effects that limit their clinical use. In view of this, the development of glycopeptides with improved chemotherapeutic properties remains the main direction in the search for new antibacterial drugs. The objective of this study was to evaluate the toxicological characteristics of new semi-synthetic glycopeptide flavancin. Acute and chronic toxicity of antibiotic was evaluated in Wistar rats. The medium lethal dose (LD₅₀) and the maximum tolerated doses (MTD) were calculated by the method of Litchfield and Wilcoxon. In the chronic toxicity study, the treatment regimen consisted of 15 daily intraperitoneal injections using two dosage levels: 6 and 10 mg/kg/day. Total doses were equivalent to MTD or LD₅₀ of flavancin, respectively. The

SUBMITTER: Treshchalin MI 

PROVIDER: S-EPMC9228439 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature