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Secondary Metabolites and Biosynthetic Gene Clusters Analysis of Deep-Sea Hydrothermal Vent-Derived Streptomyces sp. SCSIO ZS0520.

ABSTRACT: Streptomyces sp. SCSIO ZS0520 is a deep-sea hydrothermal vent-derived actinomycete. Our previous metabolism investigation showed that Streptomyces sp. SCSIO ZS0520 is a producer of cytotoxic actinopyrones. Here, another four types of secondary metabolites were identified, including six salinomycin isomers (2-7), the macrolide elaiophylin (8), the triterpene N-acetyl-aminobacteriohopanetriol (9), and the pyrone minipyrone (10). Among them, compounds 2-6 and 10 are new compounds. To understand the biosynthetic pathway of these compounds, a bioinformatic analysis of the whole genome was carried out, which identified 34 secondary metabolite biosynthetic gene clusters. Next, the biosynthetic pathways responsive to four types of products were deduced on the basis of gene function predictions and structure information. Taken together, these findings prove the metabolite potential of ZS0520 and lay the foundations to solve the remaining biosynthetic issues in four types of marine natural products.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9228677 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Secondary Metabolites and Biosynthetic Gene Clusters Analysis of Deep-Sea Hydrothermal Vent-Derived <i>Streptomyces</i> sp. SCSIO ZS0520.

Zhang Huaran H   Chen Yingying Y   Li Yanqing Y   Song Yongxiang Y   Ma Junying J   Ju Jianhua J  

Marine drugs 20220614 6

<i>Streptomyces</i> sp. SCSIO ZS0520 is a deep-sea hydrothermal vent-derived actinomycete. Our previous metabolism investigation showed that <i>Streptomyces</i> sp. SCSIO ZS0520 is a producer of cytotoxic actinopyrones. Here, another four types of secondary metabolites were identified, including six salinomycin isomers (<b>2</b>-<b>7</b>), the macrolide elaiophylin (<b>8</b>), the triterpene <i>N</i>-acetyl-aminobacteriohopanetriol (<b>9</b>), and the pyrone minipyrone (<b>10</b>). Among them, c  ...[more]

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