Eriodictyol Attenuates H₂O₂-Induced Oxidative Damage in Human Dermal Fibroblasts through Enhanced Capacity of Antioxidant Machinery.

ABSTRACT: Oxidative stress in dermal fibroblasts is strongly correlated with the aging process of the skin. The application of natural compounds that can increase the ability of dermal fibroblasts to counteract oxidative stress is a promising approach to promote skin health and beauty. Eriodictyol is a flavonoid that exerts several pharmacological actions through its antioxidant properties. However, its protective effects on dermal fibroblasts have not yet been investigated. In this study, we investigated whether eriodictyol protects human dermal fibroblasts (BJ fibroblasts) from the harmful effects of hydrogen peroxide (H₂O₂). Eriodictyol pretreatment significantly prevented necrotic cell death caused by H₂O₂ exposure. In addition, the level of 2',7'-dich

SUBMITTER: Buranasudja V 

PROVIDER: S-EPMC9228723 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature