Brain Structural and Functional Alterations in Multiple Sclerosis-Related Fatigue: A Systematic Review.

ABSTRACT: Fatigue is one of the most disabling symptoms of multiple sclerosis (MS); it influences patients' quality of life. The etiology of fatigue is complex, and its pathogenesis is still unclear and debated. The objective of this review was to describe potential brain structural and functional dysfunctions underlying fatigue symptoms in patients with MS. To reach this purpose, a systematic review was conducted of published studies comparing functional brain activation and structural brain in MS patients with and without fatigue. Electronic databases were searched until 24 February 2021. The structural and functional outcomes were extracted from eligible studies and tabulated. Fifty studies were included: 32 reported structural brain differences between patients with and without fatigue; 14 studi

SUBMITTER: Barbi C 

PROVIDER: S-EPMC9228847 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature