Stress Buffering and Longevity Effects of Amber Extract on Caenorhabditis elegans (C. elegans).

ABSTRACT: Amber is a fossilized tree resin historically used in wound healing and stress relief. Unfortunately, there is no concrete scientific evidence supporting such efficacy. Here, the stress buffering and longevity effect of Amber extract (AE) in Caenorhabditis elegans (C. elegans) was investigated. Survival assays, health span assays, Enzyme-Linked Immunosorbent Assay (ELISA), Stress biomarker detection assays, Green Fluorescence Proteins (GFP), Real Time quantitative PCR (RT-qPCR) and C. elegans mutants were employed to investigate the stress buffering and longevity effect of AE. In the study, it was observed that AE supplementation improved health span and survival in both normal and stressed worms. Additionally, AE positively regulated stress hormones (cortisol, oxytoci

SUBMITTER: Somuah-Asante S 

PROVIDER: S-EPMC9228897 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature