Acute and Subacute Safety Evaluation of Black Tea Extract (Herbt Tea Essences) in Mice.

ABSTRACT: Theabrownin (TB) is a heterogeneous biomacromolecule, extracted from tea, with many functional groups. Importantly, TB possesses diverse health benefits, such as antitumor activity and blood lipid-lowering effects. Presently, the content of TB in tea extract is relatively low. Here, we obtained a deep-processed black tea extract with a high content of TB (close to 80%), which was named Herbt Tea Essences (HTE). Currently, this study was designed to evaluate the biosafety of high-content TB products on mice. We implemented acute and subacute toxic experiments to assess its safety on organs, the serum biochemical and molecular levels. In the acute exposure study, we found that the median lethal dose (LD₅₀) value of HTE was 21.68 g/kg (21.06-24.70 g/kg, greater than 5 g/kg), sugges

SUBMITTER: Ding X 

PROVIDER: S-EPMC9228953 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature