Establishment of Repeated In Vitro Exposure System for Evaluating Pulmonary Toxicity of Representative Criteria Air Pollutants Using Advanced Bronchial Mucosa Models.

ABSTRACT: There is mounting evidence that shows the association between chronic exposure to air pollutants (particulate matter and gaseous) and onset of various respiratory impairments. However, the corresponding toxicological mechanisms of mixed exposure are poorly understood. Therefore, in this study, we aimed to establish a repeated exposure setting for evaluating the pulmonary toxicological effects of diesel exhaust particles (DEP), nitrogen dioxide (NO₂), and sulfur dioxide (SO2) as representative criterial air pollutants. Single, combined (DEP with NO₂ and SO₂), and repeated exposures were performed using physiologically relevant human bronchial mucosa models developed at the air-liquid interface (bro-ALI). The bro-ALI models were generated using human primary

SUBMITTER: Upadhyay S 

PROVIDER: S-EPMC9228979 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature