Integrating Inflammation-Responsive Prodrug with Electrospun Nanofibers for Anti-Inflammation Application.

ABSTRACT: Chronic inflammation plays a side effect on tissue regeneration, greatly inhibiting the repair or regeneration of tissues. Conventional local delivery of anti-inflammation drugs through physical encapsulation into carriers face the challenges of uncontrolled release. The construction of an inflammation-responsive prodrug to release anti-inflammation drugs depending on the occurrence of inflammation to regulate chronic inflammation is of high need. Here, we construct nanofiber-based scaffolds to regulate the inflammation response of chronic inflammation during tissue regeneration. An inflammation-sensitive prodrug is synthesized by free radical polymerization of the indomethacin-containing precursor, which is prepared by the esterification of N-(2-hydroxyethyl) acrylamide with the an

SUBMITTER: Ye J 

PROVIDER: S-EPMC9229020 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature