Flavonoids from Selaginella doederleinii Hieron and Their Antioxidant and Antiproliferative Activities.

ABSTRACT: Selaginella doederleinii Hieron. (S. doederleinii) is a traditional herb that is widely used in China to treat several ailments, but mainly cancer. Studies have been carried out to determine the phytochemicals ascribed to its pharmacological activity. However, both phytochemical and pharmacological profiles have not been fully explored as few compounds have been reported. This study evaluated the flavonoid content of the ethanol extract and its four fractions (petroleum ether, dichloromethane, ethyl acetate, and n-butanol) together with their antioxidant activity (DPPH and FRAP assays). Further, the antiproliferative activity was evaluated. Two new secondary metabolites (1 and 3) were isolated from S. doederleinii, which comprised of an apigenin sk

SUBMITTER: Muema FW 

PROVIDER: S-EPMC9229023 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature