Hepatotropic Peptides Grafted onto Maleimide-Decorated Nanoparticles: Preparation, Characterization and In Vitro Uptake by Human HepaRG Hepatoma Cells.

ABSTRACT: We recently demonstrated the strong tropism of George Baker (GB) Virus A (GBVA10-9) and Plasmodium circumsporozoite protein (CPB) derived synthetic peptides towards hepatoma cells. In a first approach, these peptides were covalently bound to poly(benzyl malate) (PMLABe₇₃) and poly(ethylene glycol)-block-PMLABe₇₃ (PEG₆₂-b-PMLABe₇₃) (co)polymers, and corresponding peptide-decorated nanoparticles (NPs) were prepared by nanoprecipitation. We showed that peptide enhanced NPs internalization by hepatoma cells. In the present work, we set up a second strategy to functionalize NPs prepared from PMLABe₇₃ derivates. First, maleimide-functionalized PMLABe₇₃ (Mal-PMLABe₇₃) and PEG₆₂-b-PM

SUBMITTER: Brossard C 

PROVIDER: S-EPMC9229302 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature