Ascorbate as a Bioactive Compound in Cancer Therapy: The Old Classic Strikes Back.

ABSTRACT: Cancer is a disease of high mortality, and its prevalence has increased steadily in the last few years. However, during the last decade, the development of modern chemotherapy schemes, new radiotherapy techniques, targeted therapies and immunotherapy has brought new hope in the treatment of these diseases. Unfortunately, cancer therapies are also associated with frequent and, sometimes, severe adverse events. Ascorbate (ascorbic acid or vitamin C) is a potent water-soluble antioxidant that is produced in most mammals but is not synthesised endogenously in humans, which lack enzymes for its synthesis. Ascorbate has antioxidant effects that correspond closely to the dose administered. Interestingly, this natural antioxidant induces oxidative stress when given intravenously at a high dose, a

SUBMITTER: Gonzalez-Montero J 

PROVIDER: S-EPMC9229419 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature