The Role of miR-217-5p in the Puromycin Aminonucleoside-Induced Morphological Change of Podocytes.

ABSTRACT: Podocytes, alternatively called glomerular epithelial cells, are terminally differentiated cells that wrap around glomerular capillaries and function as a part of the glomerular filtration barrier in the kidney. Therefore, podocyte injury with morphological alteration and detachment from glomerular capillaries leads to severe proteinuria and subsequent renal failure through glomerulosclerosis. Previous RNA sequencing analysis of primary rat podocytes exposed to puromycin aminonucleoside (PAN), a well-known experimental model of injured podocytes, identified several transcripts as being aberrantly expressed. However, how the expression of these transcripts is regulated remains unclear. MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally inhibit the expression of their tar

SUBMITTER: Ishibashi O 

PROVIDER: S-EPMC9229466 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature