Screening potential immune signatures for early-stage basal-like/triple-negative breast cancer.

ABSTRACT:

Background

Breast cancer (BC) is a highly heterogeneous disease. Among the BC molecular subtypes, basal-like/triple-negative BC (TNBC) is characterized by a high propensity for relatively early metastases and a lack of available endocrine and targeted therapies. Therefore, this study aimed to discover potential signatures for predicting the immune response in early-stage basal-like/triple-negative BC.

Method

A total of 86 cases of early-stage TNBC from the TCGA and 459 cases of normal breast tissue from GTEx were enrolled and analyzed to screen out differentially expressed genes (DEGs). Then, the prognostic effect and tumor immune cell infiltration relationship with the basal-like-specific DEGs were also evaluated.

Results

A total of 1556 DEGs, including 929 upregulat

SUBMITTER: Wu M 

PROVIDER: S-EPMC9229513 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature