Quantitative Biodistribution and Pharmacokinetics Study of GMP-Grade Exosomes Labeled with ⁸⁹Zr Radioisotope in Mice and Rats.

ABSTRACT: For the successful clinical advancement of exosome therapeutics, the biodistribution and pharmacokinetic profile of exogenous exosomes in various animal models must be determined. Compared with fluorescence or bioluminescence imaging, radionuclide imaging confers multiple advantages for the in vivo tracking of biomolecular therapeutics because of its excellent sensitivity for deep tissue imaging and potential for quantitative measurement. Herein, we assessed the quantitative biodistribution and pharmacokinetics of good manufacturing practice-grade therapeutic exosomes labeled with zirconium-89 (⁸⁹Zr) after systemic intravenous administration in mice and rats. Quantitative biodistribution analysis by positron emission tomography/computed tomography and gamma counting in mice and

SUBMITTER: Choi H 

PROVIDER: S-EPMC9229812 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature