Body Composition-Specific Asthma Phenotypes: Clinical Implications.

ABSTRACT:

Background

Previous studies have indicated the limitations of body mass index for defining disease phenotypes. The description of asthma phenotypes based on body composition (BC) has not been largely reported.

Objective

To identify and characterize phenotypes based on BC parameters in patients with asthma.

Methods

A study with two prospective observational cohorts analyzing adult patients with stable asthma (n = 541 for training and n = 179 for validation) was conducted. A body composition analysis was performed for the included patients. A cluster analysis was conducted by applying a 2-step process with stepwise discriminant analysis. Logistic regression models were used to evaluate the association between identified phenotypes and asthma exacerbations

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9229860 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature