Identifying Novel Psoriatic Disease Drug Targets Using a Genetics-Based Priority Index Pipeline.

ABSTRACT:

Background

Despite numerous genome-wide association studies conducted in psoriasis and psoriatic arthritis, only a small fraction of the identified genes has been therapeutically targeted.

Objective

We sought to identify and analyze potential therapeutic targets for psoriasis and psoriatic arthritis (PsA) using the priority index (Pi), a genetics-dependent drug target prioritization approach.

Methods

Significant genetic variants from GWAS for psoriasis, PsA, and combined psoriatic disease were annotated and run through the Pi pipeline. Potential drug targets were identified based on genomic predictors, annotation predictors, pathway enrichment, and pathway crosstalk.

Results

Several gene targets were identified for psoriasis and PsA that demonstrated biological

SUBMITTER: Bui A 

PROVIDER: S-EPMC9229908 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature