A Preliminary Study of Proinflammatory Cytokines and Depression Following West Nile Virus Infection.

ABSTRACT: West Nile virus (WNV) is a neurotropic flavivirus that can cause acute febrile illness leading to neuroinvasive disease. Depression is a well-described outcome following infection, but the underlying pathogenic mechanisms are unknown. Proinflammatory cytokines play important roles in WNV infection, but their role in depression post-WNV remains unstudied. This research aimed to retrospectively evaluate associations between proinflammatory cytokines and new onset depression in a WNV cohort. Participants with asymptomatic WNV infection were significantly less likely to report new onset depression when compared to those with symptomatic disease. Participants with encephalitis and obesity were significantly more likely to report new onset depression post-infection. Based on univariate analysis

SUBMITTER: Lino A 

PROVIDER: S-EPMC9230011 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature