NK Cell Subset Redistribution and Antibody Dependent Activation after Ebola Vaccination in Africans.

ABSTRACT: Natural killer cells play an important role in the control of viral infections both by regulating acquired immune responses and as potent innate or antibody-mediated cytotoxic effector cells. NK cells have been implicated in control of Ebola virus infections and our previous studies in European trial participants have demonstrated durable activation, proliferation and antibody-dependent NK cell activation after heterologous two-dose Ebola vaccination with adenovirus type 26.ZEBOV followed by modified vaccinia Ankara-BN-Filo. Regional variation in immunity and environmental exposure to pathogens, in particular human cytomegalovirus, have profound impacts on NK cell functional capacity. We therefore assessed the NK cell phenotype and function in African trial participants with universal expo

SUBMITTER: Wagstaffe HR 

PROVIDER: S-EPMC9230153 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature