Dietary Glycemic Load and Plasma Amyloid-β Biomarkers of Alzheimer's Disease.

ABSTRACT: Previous studies have highlighted links between a high-glycemic-load (GL) diet and Alzheimer's disease in apolipoprotein E ε4 (APOE4) carriers. However, the impact of high-GL diet on plasma amyloid-β (Aβ), an Alzheimer's disease hallmark that can be detected decades before clinical symptomatology, is unknown. This study examined the association between plasma Aβ peptides (Aβ₄₀, Aβ₄₂ concentration and Aβ₄₂/Aβ₄₀ ratio) and GL. The influence of the GL of four meal types (breakfast, lunch, afternoon snack, and dinner) was also determined. From the prospective Three-City study, 377 participants with plasma Aβ measurements, and who completed the Food Frequency Questionnaire, were selected. The association between plasma Aβ and GL was tested using an ad

SUBMITTER: Gentreau M 

PROVIDER: S-EPMC9230608 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature