Dysregulated Gene Expression in Lymphoblasts from Parkinson's Disease.

ABSTRACT: Parkinson's disease is the second largest neurodegenerative disease worldwide and is caused by a combination of genetics and environment. It is characterized by the death of neurons in the substantia nigra of the brain but is not solely a disease of the brain, as it affects multiple tissues and organs. Studying Parkinson's disease in accessible tissues such as skin and blood has increased our understanding of the disease's pathogenesis. Here, we used lymphoblast cell lines generated from Parkinson's disease patient and healthy age- and sex-matched control groups and obtained their whole-cell transcriptomes and proteomes. Our analysis revealed, in both the transcriptomes and the proteomes of PD cells, a global downregulation of genes involved in protein synthesis, as well as the upregulatio

SUBMITTER: Annesley SJ 

PROVIDER: S-EPMC9230639 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature