Construction of Double-Shelled Hollow Ag₂S@Polydopamine Nanocomposites for Fluorescence-Guided, Dual Stimuli-Responsive Drug Delivery and Photothermal Therapy.

ABSTRACT: The design and preparation of multifunctional drug carriers for combined photothermal-chemotherapy of cancer have attracted extensive attention over the past few decades. However, the development of simple-structured stimuli-responsive theranostic agents as both photothermal agents and chemotherapeutic agents remains a big challenge. Herein, a novel double-shelled nanocarrier composed of hollow Ag₂S (HAg₂S) nanospheres and a mesoporous polydopamine (MPDA) exterior shell was fabricated through a facile process. Notably, HAg₂S possesses both fluorescence and photothermal properties. MPDA acts as a drug carrier and photothermal agent. Meanwhile, the cavity structure between HAg₂S and MPDA provides more space for drug loading. The nanocarrier present

SUBMITTER: Gao M 

PROVIDER: S-EPMC9230703 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature