Molecular-Targeted Therapy of Pediatric Acute Myeloid Leukemia.

ABSTRACT: Acute myeloid leukemia (AML) accounts for approximately 15-20% of all childhood leukemia cases. The overall survival of children with acute myeloid leukemia does not exceed 82%, and the 5-year event-free survival rates range from 46% to 69%. Such suboptimal outcomes are the result of numerous mutations and epigenetic changes occurring in this disease that adversely affect the susceptibility to treatment and relapse rate. We describe various molecular-targeted therapies that have been developed in recent years to meet these challenges and were or are currently being studied in clinical trials. First introduced in adult AML, novel forms of treatment are slowly beginning to change the therapeutic approach to pediatric AML. Despite promising results of clinical trials investigating new drugs,

SUBMITTER: Obszanski P 

PROVIDER: S-EPMC9230975 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature