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Ru-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes via P-Chiral Monophosphorous Ligands.

ABSTRACT: Chiral alcohols are among the most widely applied in fine chemicals, pharmaceuticals and agrochemicals. Herein, the Ru-monophosphine catalyst formed in situ was found to promote an enantioselective addition of aliphatic aldehydes with arylboronic acids, delivering the chiral alcohols in excellent yields and enantioselectivities and exhibiting a broad scope of aliphatic aldehydes and arylboronic acids. The enantioselectivities are highly dependent on the monophosphorous ligands. The utility of this asymmetric synthetic method was showcased by a large-scale transformation.

SUBMITTER: Miao R

PROVIDER: S-EPMC9231018 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Ru-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes via <i>P</i>-Chiral Monophosphorous Ligands.

Miao Rui R Xia Yanping Y Wei Yifei Y Ouyang Lu L Luo Renshi R

Molecules (Basel, Switzerland) 20220617 12

Chiral alcohols are among the most widely applied in fine chemicals, pharmaceuticals and agrochemicals. Herein, the Ru-monophosphine catalyst formed in situ was found to promote an enantioselective addition of aliphatic aldehydes with arylboronic acids, delivering the chiral alcohols in excellent yields and enantioselectivities and exhibiting a broad scope of aliphatic aldehydes and arylboronic acids. The enantioselectivities are highly dependent on the monophosphorous ligands. The utility of th ...[more]

PMID: 35745017

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