Dihydroconiferyl Ferulate Isolated from Dendropanax morbiferus H.Lev. Suppresses Stemness of Breast Cancer Cells via Nuclear EGFR/c-Myc Signaling.

ABSTRACT: Breast cancer is the leading cause of global cancer incidence and breast cancer stem cells (BCSCs) have been identified as the target to overcome breast cancer in patients. In this study, we purified a BCSC inhibitor from Dendropanax morbiferus H.Lév. leaves through several open column and high-performance liquid chromatography via activity-based purification. The purified cancer stem cell (CSC) inhibitor was identified as dihydroconiferyl ferulate using nuclear magnetic resonance and mass spectrometry. Dihydroconiferyl ferulate inhibited the proliferation and mammosphere formation of breast cancer cells and reduced the population of CD44^high/CD24^low cells. Dihydroconiferyl ferulate also induced apoptosis, inhibited the growth of mammospheres and reduced the le

SUBMITTER: Ko YC 

PROVIDER: S-EPMC9231027 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature