Human milk oligosaccharide DSLNT and gut microbiome in preterm infants predicts necrotising enterocolitis.

ABSTRACT:

Objective

Necrotising enterocolitis (NEC) is a devastating intestinal disease primarily affecting preterm infants. The underlying mechanisms are poorly understood: mother's own breast milk (MOM) is protective, possibly relating to human milk oligosaccharide (HMO) and infant gut microbiome interplay. We investigated the interaction between HMO profiles and infant gut microbiome development and its association with NEC.

Design

We performed HMO profiling of MOM in a large cohort of infants with NEC (n=33) with matched controls (n=37). In a subset of 48 infants (14 with NEC), we also performed longitudinal metagenomic sequencing of infant stool (n=644).

Results

Concentration of a single HMO, disialyllacto-N-tetraose (DSLNT), was significantly lower in MOM received by infa

SUBMITTER: Masi AC 

PROVIDER: S-EPMC9231288 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature