Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones.

ABSTRACT: A convenient procedure of synthesis of N-carbamoyl-protected propargylic amines substituted with a cyclopropyl group from α-amido sulfones and cyclopropylacetylene is described. The reaction is catalyzed by a chiral BINOL-type zinc complex and provides the corresponding products in good yields and enantioselectivities.

SUBMITTER: Monleon A 

PROVIDER: S-EPMC9231313 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature