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Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones.

ABSTRACT: A convenient procedure of synthesis of N-carbamoyl-protected propargylic amines substituted with a cyclopropyl group from α-amido sulfones and cyclopropylacetylene is described. The reaction is catalyzed by a chiral BINOL-type zinc complex and provides the corresponding products in good yields and enantioselectivities.

SUBMITTER: Monleon A

PROVIDER: S-EPMC9231313 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones.

Monleón Alicia A Blay Gonzalo G Pedro José R JR

Molecules (Basel, Switzerland) 20220611 12

A convenient procedure of synthesis of <i>N</i>-carbamoyl-protected propargylic amines substituted with a cyclopropyl group from α-amido sulfones and cyclopropylacetylene is described. The reaction is catalyzed by a chiral BINOL-type zinc complex and provides the corresponding products in good yields and enantioselectivities. ...[more]

PMID: 35744889

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