Foot-and-Mouth Disease Virus Interserotypic Recombination in Superinfected Carrier Cattle.

ABSTRACT: Viral recombination contributes to the emergence of novel strains with the potential for altered host range, transmissibility, virulence, and immune evasion. For foot-and-mouth disease virus (FMDV), cell culture experiments and phylogenetic analyses of field samples have demonstrated the occurrence of recombination. However, the frequency of recombination and associated virus-host interactions within an infected host have not been determined. We have previously reported the detection of interserotypic recombinant FMDVs in oropharyngeal fluid (OPF) samples of 42% (5/12) of heterologously superinfected FMDV carrier cattle. The present investigation consists of a detailed analysis of the virus populations in these samples including identification and characterization of additional interseroty

SUBMITTER: Fish I 

PROVIDER: S-EPMC9231328 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature