Engineered Nanoparticulate Vaccines to Combat Recurring and Pandemic Influenza Threats.

ABSTRACT: Reoccurring seasonal flu epidemics and occasional pandemics are among the most severe threats to public health. Current seasonal influenza vaccines provide limited protection against drifted circulating strains and no protection against influenza pandemics. Next-generation influenza vaccines, designated as universal influenza vaccines, should be safe, affordable, and elicit long-lasting cross-protective influenza immunity. Nanotechnology plays a critical role in the development of such novel vaccines. Engineered nanoparticles can incorporate multiple advantageous properties into the same nanoparticulate platforms to improve vaccine potency and breadth. These immunological properties include virus-like biomimicry, high antigen-load, controlled antigen release, targeted delivery, and inducti

SUBMITTER: Dong C 

PROVIDER: S-EPMC9231845 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature