Long term outcomes of patients with tuberculous meningitis: The impact of drug resistance.

ABSTRACT:

Background

Little is known about the impact of drug-resistance on clinical outcomes among patients with tuberculosis meningitis (TBM).

Methods

A retrospective cohort study among patients treated for TBM in Tbilisi, Georgia. We performed medical chart abstraction to collect patient data. Long-term vital status was assessed using the Georgia National Death Registry. We utilized a Cox proportional-hazards model to evaluate the association of drug-resistance and mortality.

Results

Among 343 TBM suspects, 237 had a presentation consistent with TBM. Drug resistance was suspected (n = 5) or confirmed (n = 31) in 36 patients including 30 with multidrug- or rifampin-resistance and 6 with isoniazid-resistance. Thirty-four patients had HIV. The median follow-up time was 1331 day

SUBMITTER: Evans EE 

PROVIDER: S-EPMC9232145 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature