Tongue immune compartment analysis reveals spatial macrophage heterogeneity.

ABSTRACT: The tongue is a unique muscular organ situated in the oral cavity where it is involved in taste sensation, mastication, and articulation. As a barrier organ, which is constantly exposed to environmental pathogens, the tongue is expected to host an immune cell network ensuring local immune defence. However, the composition and the transcriptional landscape of the tongue immune system are currently not completely defined. Here, we characterised the tissue-resident immune compartment of the murine tongue during development, health and disease, combining single-cell RNA-sequencing with in situ immunophenotyping. We identified distinct local immune cell populations and described two specific subsets of tongue-resident macrophages occupying discrete anatomical niches. Cx3cr1⁺ m

SUBMITTER: Lyras EM 

PROVIDER: S-EPMC9232218 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature