Prediction of Immune Infiltration Diagnostic Gene Biomarkers in Kawasaki Disease.

ABSTRACT: Kawasaki disease (KD) is characterized by disorder of immune response with unknown etiology. Immune cells may be closely related to the onset of KD. The focus of this research was to evaluate the significance of the infiltration of immune cells for this disease and find possible diagnostic biomarkers for KD. The Gene Expression Omnibus database was utilized to retrieve two freely accessible gene expression patterns (GSE68004 and GSE18606 datasets) from human KD and control specimens. 114 KD, as well as 46 control specimens, were searched for obtaining differentially expressed genes (DEGs). Candidate biological markers were determined utilizing the support vector machine recursive feature elimination and the least absolute shrinkage and selection operator regression model analysis. To asses

SUBMITTER: Ba H 

PROVIDER: S-EPMC9232301 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature