Mutational dynamics across VOCs in International travellers and Community transmission underscores importance of Spike-ACE2 interaction.

ABSTRACT:

Background

Emergence of SARS-CoV-2 VOCs at different time points through COVID-19 pandemic raised concern for increased transmissibility, infectivity and vaccination breakthroughs.

Methods

1567 international travellers plus community transmission COVID-19 cases were analysed for mutational profile of VOCS, that led to notable waves in India, namely Alpha, Delta, and Omicron. Spike mutations in Linkage Disequilibrium were investigated for potential impact on structural and functional changes of Spike-ACE2.

Results

ORF1ab and spike harboured diverse mutational signatures for each lineage. B.1.617.2 and AY. * demonstrated comparable profile, yet non-clade defining mutations were majorly unique between international vs community samples. Contrarily, Omicron lineages showe

SUBMITTER: Mehta P 

PROVIDER: S-EPMC9232397 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature