Integrated Multi-Omics Analysis Model to Identify Biomarkers Associated With Prognosis of Breast Cancer.

ABSTRACT:

Background

With the rapid development and wide application of high-throughput sequencing technology, biomedical research has entered the era of large-scale omics data. We aim to identify genes associated with breast cancer prognosis by integrating multi-omics data.

Method

Gene-gene interactions were taken into account, and we applied two differential network methods JDINAC and LGCDG to identify differential genes. The patients were divided into case and control groups according to their survival time. The TCGA and METABRIC database were used as the training and validation set respectively.

Result

In the TCGA dataset, C11orf1, OLA1, RPL31, SPDL1 and IL33 were identified to be associated with prognosis of breast cancer. In the METABRIC database, ZNF273, ZBTB37, TRIM52,

SUBMITTER: Fan Y 

PROVIDER: S-EPMC9232398 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature