Analysis of commonly expressed genes between first trimester fetal heart and placenta cell types in the context of congenital heart disease.

ABSTRACT: Congenital heart disease (CHD) is often associated with fetal growth abnormalities. During the first trimester of pregnancy, the heart and placenta develop concurrently, and share key developmental pathways. It is hypothesized that defective morphogenesis of either organ is synergistically linked. However, many studies determined to understand the mechanisms behind CHD overlook the contribution of the placenta. In this study, we aimed to identify commonly expressed genes between first trimester heart and placenta cells using two publicly available single cell sequencing databases. Using a systematic computational approach, we identified 328 commonly expressed genes between heart and placenta endothelial cells and enrichment in pathways including Vasculature Development (GO:0001944, FDR 2.9

SUBMITTER: Wilson RL 

PROVIDER: S-EPMC9232495 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature