Teprotumumab for thyroid eye disease: early response is not required for benefit.

ABSTRACT:

Purpose

In recent trials, 50% of patients treated with teprotumumab for thyroid eye disease had significant improvements in proptosis at 6 weeks. However, a small subgroup of patients did not have a significant response by week 12. We examine the outcomes at week 24 in patients from both trials who had little or no proptosis response at week 12.

Design

In this post hoc analysis, data from teprotumumab-treated patients in the placebo-controlled randomized phases 2 and 3 trials were reviewed.

Methods

Patients treated with teprotumumab or placebo with a ≤2 mm reduction from baseline in proptosis at week 12 and completed assessments at both the weeks 12 and 24 visits were included. The main outcome measures were a change in proptosis, clinical activity score (CAS) and dip

SUBMITTER: Ugradar S 

PROVIDER: S-EPMC9232498 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature