Tear cytokine profiles in patients with extranodal marginal zone B-cell lymphoma of the ocular adnexa.

ABSTRACT:

Objectives

To comprehensively analyse the tear cytokine levels of patients with extranodal marginal zone B-cell lymphoma (EMZL) of the ocular adnexa (OA), and the association with clinical characteristics.

Methods

Tear cytokine concentrations of 21 OA-EMZL patients and 14 age- and sex-matched healthy controls were measured using a 27-multiplex bead analysis on a Luminex system. Tear break-up time, corneal fluorescent staining and other clinical and demographic data were collected as well. The diagnosis of OA-EMZL was established based on the incisional biopsy and histopathology.

Results

The concentrations of interleukin-1 receptor antagonist (IL-1RA) and IL-8, and the ratio of IL-1RA/IL-1β were significantly increased in OA-EMZL tear samples (all P < 0.05), while the

SUBMITTER: Xiao W 

PROVIDER: S-EPMC9232588 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature