Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration.

ABSTRACT: The wound healing response is one of most primitive and conserved physiological responses in the animal kingdom, as restoring tissue integrity/homeostasis can be the difference between life and death. Wound healing in mammals is mediated by immune cells and inflammatory signaling molecules that regulate tissue resident cells, including local progenitor cells, to mediate closure of the wound through formation of a scar. Proteoglycan 4 (PRG4), a protein found throughout the animal kingdom from fish to elephants, is best known as a glycoprotein that reduces friction between articulating surfaces (e.g. cartilage). Previously, PRG4 was also shown to regulate the inflammatory and fibrotic response. Based on this, we asked whether PRG4 plays a role in the wound healing response. Using an ear woun

SUBMITTER: Krawetz RJ 

PROVIDER: S-EPMC9232611 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature