A miniaturized 3D printed pressure regulator (µPR) for microfluidic cell culture applications.

ABSTRACT: Well-defined fluid flows are the hallmark feature of microfluidic culture systems and enable precise control over biophysical and biochemical cues at the cellular scale. Microfluidic flow control is generally achieved using displacement-based (e.g., syringe or peristaltic pumps) or pressure-controlled techniques that provide numerous perfusion options, including constant, ramped, and pulsed flows. However, it can be challenging to integrate these large form-factor devices and accompanying peripherals into incubators or other confined environments. In addition, microfluidic culture studies are primarily carried out under constant perfusion conditions and more complex flow capabilities are often unused. Thus, there is a need for a simplified flow control platform that provides standard perfu

SUBMITTER: Hsu MC 

PROVIDER: S-EPMC9232624 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature