A combination of direct reversion and nucleotide excision repair counters the mutagenic effects of DNA carboxymethylation.

ABSTRACT: Distinct cellular DNA damage repair pathways maintain the structural integrity of DNA and protect it from the mutagenic effects of genotoxic exposures and processes. The occurrence of O⁶-carboxymethylguanine (O⁶-CMG) has been linked to meat consumption and hypothesized to contribute to the development of colorectal cancer. However, the cellular fate of O⁶-CMG is poorly characterized and there is contradictory data in the literature as to how repair pathways may protect cells from O⁶-CMG mutagenicity. To better address how cells detect and remove O⁶-CMG, we evaluated the role of two DNA repair pathways in counteracting the accumulation and toxic effects of O⁶-CMG. We found that cells deficient in either the direct repair prot

SUBMITTER: Aloisi CMN 

PROVIDER: S-EPMC9232693 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature