Advances in molecular pathogenesis of hidradenitis suppurativa: Dysregulated keratins and ECM signaling.

ABSTRACT: Hidradenitis suppurativa (HS) is characterized by deep-seated, highly inflamed, and painful lumps/abscesses, fistulae, and sinus tracts that grow extensively deep in the dermis and are highly immunogenic in nature. In about one-third of the HS patients there is strong evidence for the role of γ-secretase mutations along with dysregulated Notch signaling. However, the contribution of dysregulated Notch signaling in HS pathogenesis in relation to hair follicle alterations and hyper-activation of the immune system remains undefined. A genome-wide association study (GWAS), proteomic data and functional investigations of identified sequence variants in HS pathology are not fully revealing. The disease initiation or progression may involve bacterial infection besides intrinsic functional defects

SUBMITTER: Kashyap MP 

PROVIDER: S-EPMC9232849 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature