The Impact of Methenamine Hippurate Treatment on Urothelial Integrity and Bladder Inflammation in Aged Female Mice and Women With Urinary Tract Infections.

ABSTRACT:

Importance

Antibiotics are commonly used to treat and prevent urinary tract infection (UTI), but resistance is growing. Nonantibiotic prophylaxis such as methenamine hippurate (MH) shows clinical promise, but its impact on bladder factors influencing recurrent UTIs (rUTIs) is not well described.

Objective

The aim of the study was to examine the effect of MH on bladder inflammation and barrier function in aged mice and women with rUTI.

Study design

This study included urine samples from an experimental study involving aged female mice with and without methenamine treatment as well as women with rUTI who received either no prophylaxis, MH alone, vaginal estrogen therapy and/or d-mannose alone, or MH in addition to vaginal estrogen therapy and/or d-mannose. We performed

SUBMITTER: Sawhill JL 

PROVIDER: S-EPMC9232912 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature