Astrocyte Molecular Clock Function in the Nucleus Accumbens Is Important for Reward-Related Behavior.

ABSTRACT:

Background

Substance use disorders are associated with disruptions in circadian rhythms. Both human and animal work have shown the integral role for circadian clocks in the modulation of reward behaviors. Astrocytes have emerged as key regulators of circadian rhythmicity. However, no studies to date have identified the role of circadian astrocyte function in the nucleus accumbens (NAc), a hub for reward regulation, or determined the importance of these rhythms for reward-related behavior.

Methods

Using astrocyte-specific RNA sequencing across time of day, we first characterized diurnal variation of the NAc astrocyte transcriptome. We then investigated the functional significance of this circadian regulation through viral-mediated disruption of molecular clock function in NAc

SUBMITTER: Becker-Krail DD 

PROVIDER: S-EPMC9232937 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature