1,25-Dihydroxyvitamin D3 suppresses CD4⁺ T-cell effector functionality by inhibition of glycolysis.

ABSTRACT: In CD4⁺ T helper cells, the active form of vitamin D₃ , 1,25-dihydroxyvitamin D₃ (1,25D) suppresses production of inflammatory cytokines, including interferon-gamma (IFN-γ), but the mechanisms for this are not yet fully defined. In innate immune cells, response to 1,25D has been linked to metabolic reprogramming. It is unclear whether 1,25D has similar effects on CD4⁺ T cells, although it is known that antigen stimulation of these cells promotes an anabolic metabolic phenotype, characterized by high rates of aerobic glycolysis to support clonal expansion and effector cytokine expression. Here, we performed in-depth analysis of metabolic capacity and pathway usage, employing extracellular flux and stable isotope-based tracing approaches, in CD4

SUBMITTER: Bishop EL 

PROVIDER: S-EPMC9232967 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature