The influence of cystathionine on neurochemical quantification in brain tumor in vivo MR spectroscopy.

ABSTRACT:

Purpose

To evaluate the ability of the PRESS sequence (T_E  = 97 ms, optimized for 2-hydroxyglutarate detection) to detect cystathionine in gliomas and the effect of the omission of cystathionine on the quantification of the full neurochemical profile.

Methods

Twenty-three subjects with a glioma were retrospectively included based on the availability of both MEGA-PRESS and PRESS acquisitions at 3T, and the presence of the cystathionine signal in the edited MR spectrum. In eight subjects, the PRESS acquisition was performed also in normal tissue. Metabolite quantification was performed using LCModel and simulated basis sets. The LCModel analysis for the PRESS data was performed with and without cystathionine.

Results

All subjects with glioma had detectable cy

SUBMITTER: Branzoli F 

PROVIDER: S-EPMC9232981 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature