Imaging versus electrographic connectivity in human mood-related fronto-temporal networks.

ABSTRACT:

Background

The efficacy of psychiatric DBS is thought to be driven by the connectivity of stimulation targets with mood-relevant fronto-temporal networks, which is typically evaluated using diffusion-weighted tractography.

Objective

Leverage intracranial electrophysiology recordings to better predict the circuit-wide effects of neuromodulation to white matter targets. We hypothesize strong convergence between tractography-predicted structural connectivity and stimulation-induced electrophysiological responses.

Methods

Evoked potentials were elicited by single-pulse stimulation to two common DBS targets for treatment-resistant depression - the subcallosal cingulate (SCC) and ventral capsule/ventral striatum (VCVS) - in two patients undergoing DBS with stereo-electroenc

SUBMITTER: Adkinson JA 

PROVIDER: S-EPMC9232982 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature