A Modified Progressive Supranuclear Palsy Rating Scale for Virtual Assessments.

ABSTRACT:

Background

The reliability of the Progressive Supranuclear Palsy Rating Scale (PSPRS) using teleneurology has not been assessed.

Objectives

To test whether removing items inadequately assessed by video would impact measurement of PSP severity and progression.

Methods

We performed secondary analyses of two data sets: the phase 2/3 trial of Davunetide in PSP and a large single-center cohort. We examined two modifications of the PSPRS: (1) removing neck rigidity, limb rigidity, and postural stability (25 items; mPSPRS-25) and (2) also removing three ocular motor items and limb dystonia (21 items; mPSPRS-21). Proportional agreement relative to the possible total scores was measured using the intraclass correlation coefficient, compared to the original PSPRS baseline value

SUBMITTER: Wills AM 

PROVIDER: S-EPMC9232989 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature