Effect of menopausal hormone therapy on arterial wall echomorphology: Results from the Early versus Late Intervention Trial with Estradiol (ELITE).

ABSTRACT:

Objective

To evaluate the effect of hormone therapy (HT) on arterial wall composition by ultrasound.

Background

The effect of HT on the progression of subclinical atherosclerosis has been well-described using measurements of common carotid artery (CCA) wall thickness. However, it is unknown whether the change in arterial wall anatomic structure is accompanied by an effect of HT on arterial wall composition.

Methods

A total of 643 healthy postmenopausal women divided into two strata according to the time since menopause (<6 years, the early-postmenopause group; or >10 years, the late-postmenopause group) were randomized to receive either active treatment or placebo. For hysterectomized women, the active treatment was oral micronized 17β-estradiol 1 mg/day; for women wi

SUBMITTER: Karim R 

PROVIDER: S-EPMC9232990 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature