Circulating bile acid concentrations and non-alcoholic fatty liver disease in Guatemala.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is a major liver disease worldwide. Bile acid dysregulation may be a key feature in its pathogenesis and progression.

Aims

To characterise the relationship between bile acid levels and NAFLD at the population level METHODS: We conducted a cross-sectional study in Guatemala in 2016 to examine the prevalence of NAFLD. Participants (n = 415) completed questionnaires, donated blood samples and had a brief medical exam. NAFLD was determined by calculation of the fatty liver index. The levels of 15 circulating bile acids were determined by LC-MS/MS. Adjusted prevalence odds ratios (POR_adj ) and 95% CI were calculated to examine the relationships between bile acid levels (in tertiles) and NAFLD.

Results

Persons

SUBMITTER: Rivera-Andrade A 

PROVIDER: S-EPMC9233027 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature