The age-dependent association of risk factors with pancreatic cancer.

ABSTRACT:

Background

Pancreatic cancer presents as advanced disease in >80% of patients; yet, appropriate ages to consider prevention and early detection strategies are poorly defined. We investigated age-specific associations and attributable risks of pancreatic cancer for established modifiable and non-modifiable risk factors.

Patients and methods

We included 167 483 participants from two prospective US cohort studies with 1190 incident cases of pancreatic cancer during >30 years of follow-up; 5107 pancreatic cancer cases and 8845 control participants of European ancestry from a completed multicenter genome-wide association study (GWAS); and 248 893 pancreatic cancer cases documented in the US Surveillance, Epidemiology, and End Results (SEER) Program. Across different age categorie

SUBMITTER: Yuan C 

PROVIDER: S-EPMC9233063 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature